Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma

Spatial downregulation of CD74 signatures may drive invasive component development in part-solid lung adenocarcinoma

Blog Article

Summary: Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma.To define the spatial composition and evolutionary trajectories of early-stage lung adenocarcinoma, we combined spatial transcriptomics (ST) and pathological annotations from 20 part-solid nodules (PSNs), four of which were matched with single-cell RNA sequencing.Two malignant cell populations (MC1 and MC2) were identified, and Wooden Dollhouse Accessories a linear evolutionary relationship was observed.Compared to MC2, the pre-existing malignant MC1 exhibited a lower metastatic signature, corresponding to the preinvasive Cleaners component (lepidic) on pathology and the ground glass component on PSN imaging.Higher immune infiltration was observed among MC1 regions in ST profiles, and further analysis revealed that macrophages may be involved in this process through the CD74 axis.

This work provides deeper insights into the evolutionary process and spatial immune cell composition behind PSNs and highlights the mechanisms of immune escape behind this adenocarcinoma trajectory.